53 research outputs found
Nanoscale phase-engineering of thermal transport with a Josephson heat modulator
Macroscopic quantum phase coherence has one of its pivotal expressions in the
Josephson effect [1], which manifests itself both in charge [2] and energy
transport [3-5]. The ability to master the amount of heat transferred through
two tunnel-coupled superconductors by tuning their phase difference is the core
of coherent caloritronics [4-6], and is expected to be a key tool in a number
of nanoscience fields, including solid state cooling [7], thermal isolation [8,
9], radiation detection [7], quantum information [10, 11] and thermal logic
[12]. Here we show the realization of the first balanced Josephson heat
modulator [13] designed to offer full control at the nanoscale over the
phase-coherent component of thermal currents. Our device provides
magnetic-flux-dependent temperature modulations up to 40 mK in amplitude with a
maximum of the flux-to-temperature transfer coefficient reaching 200 mK per
flux quantum at a bath temperature of 25 mK. Foremost, it demonstrates the
exact correspondence in the phase-engineering of charge and heat currents,
breaking ground for advanced caloritronic nanodevices such as thermal splitters
[14], heat pumps [15] and time-dependent electronic engines [16-19].Comment: 6+ pages, 4 color figure
Sisyphus cooling and amplification by a superconducting qubit
Laser cooling of the atomic motion paved the way for remarkable achievements
in the fields of quantum optics and atomic physics, including Bose-Einstein
condensation and the trapping of atoms in optical lattices. More recently
superconducting qubits were shown to act as artificial two-level atoms,
displaying Rabi oscillations, Ramsey fringes, and further quantum effects.
Coupling such qubits to resonators brought the superconducting circuits into
the realm of quantum electrodynamics (circuit QED). It opened the perspective
to use superconducting qubits as micro-coolers or to create a population
inversion in the qubit to induce lasing behavior of the resonator. Furthering
these analogies between quantum optical and superconducting systems we
demonstrate here Sisyphus cooling of a low frequency LC oscillator coupled to a
near-resonantly driven superconducting qubit. In the quantum optics setup the
mechanical degrees of freedom of an atom are cooled by laser driving the atom's
electronic degrees of freedom. Here the roles of the two degrees of freedom are
played by the LC circuit and the qubit's levels, respectively. We also
demonstrate the counterpart of the Sisyphus cooling, namely Sisyphus
amplification. Parallel to the experimental demonstration we analyze the system
theoretically and find quantitative agreement, which supports the
interpretation and allows us to estimate system parameters.Comment: 7 pages, 4 figure
Tripartite interactions between two phase qubits and a resonant cavity
The creation and manipulation of multipartite entangled states is important
for advancements in quantum computation and communication, and for testing our
fundamental understanding of quantum mechanics and precision measurements.
Multipartite entanglement has been achieved by use of various forms of quantum
bits (qubits), such as trapped ions, photons, and atoms passing through
microwave cavities. Quantum systems based on superconducting circuits have been
used to control pair-wise interactions of qubits, either directly, through a
quantum bus, or via controllable coupling. Here, we describe the first
demonstration of coherent interactions of three directly coupled
superconducting quantum systems, two phase qubits and a resonant cavity. We
introduce a simple Bloch-sphere-like representation to help one visualize the
unitary evolution of this tripartite system as it shares a single microwave
photon. With careful control and timing of the initial conditions, this leads
to a protocol for creating a rich variety of entangled states. Experimentally,
we provide evidence for the deterministic evolution from a simple product
state, through a tripartite W-state, into a bipartite Bell-state. These
experiments are another step towards deterministically generating multipartite
entanglement in superconducting systems with more than two qubits
Coupling Superconducting Qubits via a Cavity Bus
Superconducting circuits are promising candidates for constructing quantum
bits (qubits) in a quantum computer; single-qubit operations are now routine,
and several examples of two qubit interactions and gates having been
demonstrated. These experiments show that two nearby qubits can be readily
coupled with local interactions. Performing gates between an arbitrary pair of
distant qubits is highly desirable for any quantum computer architecture, but
has not yet been demonstrated. An efficient way to achieve this goal is to
couple the qubits to a quantum bus, which distributes quantum information among
the qubits. Here we show the implementation of such a quantum bus, using
microwave photons confined in a transmission line cavity, to couple two
superconducting qubits on opposite sides of a chip. The interaction is mediated
by the exchange of virtual rather than real photons, avoiding cavity induced
loss. Using fast control of the qubits to switch the coupling effectively on
and off, we demonstrate coherent transfer of quantum states between the qubits.
The cavity is also used to perform multiplexed control and measurement of the
qubit states. This approach can be expanded to more than two qubits, and is an
attractive architecture for quantum information processing on a chip.Comment: 6 pages, 4 figures, to be published in Natur
Quantum Computing
Quantum mechanics---the theory describing the fundamental workings of
nature---is famously counterintuitive: it predicts that a particle can be in
two places at the same time, and that two remote particles can be inextricably
and instantaneously linked. These predictions have been the topic of intense
metaphysical debate ever since the theory's inception early last century.
However, supreme predictive power combined with direct experimental observation
of some of these unusual phenomena leave little doubt as to its fundamental
correctness. In fact, without quantum mechanics we could not explain the
workings of a laser, nor indeed how a fridge magnet operates. Over the last
several decades quantum information science has emerged to seek answers to the
question: can we gain some advantage by storing, transmitting and processing
information encoded in systems that exhibit these unique quantum properties?
Today it is understood that the answer is yes. Many research groups around the
world are working towards one of the most ambitious goals humankind has ever
embarked upon: a quantum computer that promises to exponentially improve
computational power for particular tasks. A number of physical systems,
spanning much of modern physics, are being developed for this task---ranging
from single particles of light to superconducting circuits---and it is not yet
clear which, if any, will ultimately prove successful. Here we describe the
latest developments for each of the leading approaches and explain what the
major challenges are for the future.Comment: 26 pages, 7 figures, 291 references. Early draft of Nature 464, 45-53
(4 March 2010). Published version is more up-to-date and has several
corrections, but is half the length with far fewer reference
Demonstration of Two-Qubit Algorithms with a Superconducting Quantum Processor
By harnessing the superposition and entanglement of physical states, quantum
computers could outperform their classical counterparts in solving problems of
technological impact, such as factoring large numbers and searching databases.
A quantum processor executes algorithms by applying a programmable sequence of
gates to an initialized register of qubits, which coherently evolves into a
final state containing the result of the computation. Simultaneously meeting
the conflicting requirements of long coherence, state preparation, universal
gate operations, and qubit readout makes building quantum processors
challenging. Few-qubit processors have already been shown in nuclear magnetic
resonance, cold ion trap and optical systems, but a solid-state realization has
remained an outstanding challenge. Here we demonstrate a two-qubit
superconducting processor and the implementation of the Grover search and
Deutsch-Jozsa quantum algorithms. We employ a novel two-qubit interaction,
tunable in strength by two orders of magnitude on nanosecond time scales, which
is mediated by a cavity bus in a circuit quantum electrodynamics (cQED)
architecture. This interaction allows generation of highly-entangled states
with concurrence up to 94%. Although this processor constitutes an important
step in quantum computing with integrated circuits, continuing efforts to
increase qubit coherence times, gate performance and register size will be
required to fulfill the promise of a scalable technology.Comment: 6 pages, 1 table, 4 figures, and Supplementary Information (3 pages,
3 figures); Expanded author list, updated references, and minor improvements
to text and figure
Amplitude Spectroscopy of a Solid-State Artificial Atom
The energy-level structure of a quantum system plays a fundamental role in
determining its behavior and manifests itself in a discrete absorption and
emission spectrum. Conventionally, spectra are probed via frequency
spectroscopy whereby the frequency \nu of a harmonic driving field is varied to
fulfill the conditions \Delta E = h \nu, where the driving field is resonant
with the level separation \Delta E (h is Planck's constant). Although this
technique has been successfully employed in a variety of physical systems,
including natural and artificial atoms and molecules, its application is not
universally straightforward, and becomes extremely challenging for frequencies
in the range of 10's and 100's of gigahertz. Here we demonstrate an alternative
approach, whereby a harmonic driving field sweeps the atom through its
energy-level avoided crossings at a fixed frequency, surmounting many of the
limitations of the conventional approach. Spectroscopic information is obtained
from the amplitude dependence of the system response. The resulting
``spectroscopy diamonds'' contain interference patterns and population
inversion that serve as a fingerprint of the atom's spectrum. By analyzing
these features, we determine the energy spectrum of a manifold of states with
energies from 0.01 to 120 GHz \times h in a superconducting artificial atom,
using a driving frequency near 0.1 GHz. This approach provides a means to
manipulate and characterize systems over a broad bandwidth, using only a single
driving frequency that may be orders of magnitude smaller than the energy
scales being probed.Comment: 12 pages, 13 figure
Does weight loss improve semen quality and reproductive hormones? results from a cohort of severely obese men
<p>Abstract</p> <p>Background</p> <p>A high body mass index (BMI) has been associated with reduced semen quality and male subfecundity, but no studies following obese men losing weight have yet been published. We examined semen quality and reproductive hormones among morbidly obese men and studied if weight loss improved the reproductive indicators.</p> <p>Methods</p> <p>In this pilot cohort study, 43 men with BMI > 33 kg/m<sup>2 </sup>were followed through a 14 week residential weight loss program. The participants provided semen samples and had blood samples drawn, filled in questionnaires, and had clinical examinations before and after the intervention. Conventional semen characteristics as well as sperm DNA integrity, analysed by the sperm chromatin structure assay (SCSA) were obtained. Serum levels of testosterone, estradiol, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH) and inhibin B (Inh-B) were measured.</p> <p>Results</p> <p>Participants were from 20 to 59 years of age (median = 32) with BMI ranging from 33 to 61 kg/m<sup>2</sup>. At baseline, after adjustment for potential confounders, BMI was inversely associated with sperm concentration (p = 0.02), total sperm count (p = 0.02), sperm morphology (p = 0.04), and motile sperm (p = 0.005) as well as testosterone (p = 0.04) and Inh-B (p = 0.04) and positively associated to estradiol (p < 0.005). The median (range) percentage weight loss after the intervention was 15% (3.5 - 25.4). Weight loss was associated with an increase in total sperm count (p = 0.02), semen volume (p = 0.04), testosterone (p = 0.02), SHBG (p = 0.03) and AMH (p = 0.02). The group with the largest weight loss had a statistically significant increase in total sperm count [193 millions (95% CI: 45; 341)] and normal sperm morphology [4% (95% CI: 1; 7)].</p> <p>Conclusion</p> <p>This study found obesity to be associated with poor semen quality and altered reproductive hormonal profile. Weight loss may potentially lead to improvement in semen quality. Whether the improvement is a result of the reduction in body weight per se or improved lifestyles remains unknown.</p
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes
dentification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 x 10(-8)) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.Peer reviewe
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